10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 2 2015 (April - June) The aim of this study was to evaluate the lessThan i greaterThan in vitro lessThan /i greaterThan probiotic properties of lessThan i greaterThan Pediococcus pentosaceus lessThan /i greaterThan CECT 8330 and lessThan i greaterThan Bifidobacterium longum lessThan /i greaterThan CECT 7894 and their suitability as candidates for treating infantile excessive crying syndrome. Results reveal that lessThan i greaterThan P. pentosaceus lessThan /i greaterThan is able to induce IL-10 production, and the combination with lessThan i greaterThan B. longum lessThan /i greaterThan CECT 7894 shows a broad spectrum inhibitory activity against pathogens. lessThan i greaterThan P. pentosaceus lessThan /i greaterThan CECT 8330 and lessThan i greaterThan B. longum lessThan /i greaterThan CECT 7894 were combined in a single formula which was confirmed to be well tolerated in a pilot, randomized, double-blind clinical trial in infants with excessive crying syndrome. Moreover, a trend towards a greater reduction in daily crying time was observed in the probiotic group compared to placebo (81.0 ± 11.2 vs 54.1 ± 8.6 reduction in minutes per day, respectively; P=0.083). Given the small sample size, these analyses should be repeated in a larger study. JONATHAN SANTAS, MARI CARMEN FUENTES, RAMON TORMO, RAFAEL GUAYTA-ESCOLIES, ELISABET LÁZARO AND JORDI CUÑÉ Pediococcus pentosaceus, Bifidobacterium longum, Lactobacillus reuteri, infant colic, excessive crying. 458-466