International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 6 Issue 2
2015 (April - June)
EFFICACY OF ZINCODERM G CREAM AGAINST WOUND INFECTION BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS IN SPRAGUEDAWLEY RATS
A fixed drug combinations (FDC) of clobetasol, gentamicin and Zinc namely Zincoderm G cream is available in the market. There are studies which shows the efficacy of each component in bacterial infections, but as FDC including Zinc has not been reported yet. A study was undertaken to evaluate the efficacy of Zincoderm G cream in burn wound infected with methicillin-resistant lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan . Methods: A total of 18 Sprague-Dawley rats (male, pathogen free, 6-8 weeks old) were used in this study. The rats were divided into 3 groups of 6 rats each. 25-30 mg of test drugs (Zincoderm G cream with or without Zinc) was applied on lessThan i greaterThan S.aureus lessThan /i greaterThan infected burn wound affected area of back of rats for two weeks. Degree of bacterial infection was assessed by quantification of bacteria. There was 30% mortality seen in both MRSA toxic control (cream base) and MRSA positive control (Zincoderm G cream without Zinc) groups. Only 10% mortality was observed in the MRSA group which was treated with Zincoderm G cream with Zinc. But, there was no significant difference found in MRSA bacterial concentration (number of CFU/ml wound fluid; after treatment) for both Zincoderm G with/without Zinc when compared with the MRSA toxic control (cream base) groupAddition of Zinc to Zincoderm G did not exhibit distinct killing profile against MRSA. We found that Zincoderm G cream with Zinc could not exhibit the distinct killing profiles against MRSA.
SATYAM SM, BAIRY KL, MUSHARAF S, FERNANDES D AND SHASHIDHAR V.
Zincoderm G cream, MRSA, Infection, Burn-wound
446-449