10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 2 2015 (April - June) Our objective is to evaluate the antibacterial and antioxidant activity of ethanolic extracts of lessThan i greaterThan Plectranthus mollis (P.mollis) lessThan /i greaterThan and lessThan i greaterThan Salvia officinalis lessThan /i greaterThan ( lessThan i greaterThan S. officinalis lessThan /i greaterThan ) leaves locally used for treatment of microbial infection in Nilgiris of India. Antibacterial activity was determined by using agar diffusion and broth dilution methods against seven microorganisms. The antioxidant potential was assessed by using 2,2 diphenyl -1- picryl hydrazine (DPPH) scavenging assay. Ethanolic extract of lessThan i greaterThan P. mollis lessThan /i greaterThan showed antibacterial activity in the following order viz lessThan i greaterThan Pseudomonas aerugenosa lessThan /i greaterThan (20 mm, MIC of 12.5 µg/ml), lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan (19 mm, MIC of 6.3µg/ml), lessThan i greaterThan Bacillus cereus lessThan /i greaterThan (18 mm, MIC of 25µg/ml), lessThan i greaterThan Salmonella typhimurium lessThan /i greaterThan (16 mm, MIC of 25µg/ml) and lessThan i greaterThan Bacillus subtilis lessThan /i greaterThan (14 mm, MIC of 12.5µg/ml) lessThan i greaterThan . Escherichia coli lessThan /i greaterThan and lessThan i greaterThan Klebsiella pneumoniae lessThan /i greaterThan were resistant to ethanolic extract of P.mollis, whereas the ethanolic extract of lessThan i greaterThan S. officinalis lessThan /i greaterThan and control (DMSO) did not show any inhibition against all the bacteria tested. Both the extracts possess marked DPPH radical scavenging activities compared to the reference antioxidant ascorbic acid in a dose dependent manner with the IC lessThan sub greaterThan 50 lessThan /sub greaterThan values being 73.26µg/ml, 107µg/ml and 40.17µg/ml for lessThan i greaterThan P. mollis lessThan /i greaterThan , lessThan i greaterThan S. officinalis lessThan /i greaterThan and ascorbic acid respectively. Based on the results, it may be confirmed that the antioxidants might have enhanced the antibacterial activities of lessThan i greaterThan P.mollis lessThan /i greaterThan . But lessThan i greaterThan S. officinalis lessThan /i greaterThan did not show any antibacterial activities even though it has good antioxidant potential than lessThan i greaterThan P.mollis lessThan /i greaterThan . Further studies on isolation and purification of compounds that are responsible for their antibacterial and antioxidant activities are needed. G.RAMU AND G. KRISHNAMOHAN P. mollis, S. officinalis, Ethanolic extract, Antibacterial activity, Minimum inhibitory concentration, Antioxidant activity. 416-421