10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 2 2015 (April - June) Liver transplantation is the surgical treatment of choice for several irreversible liver diseases where a partially or completely diseased liver is replaced with a healthy liver. The continued use of immunosuppressant causes certain serious consequences such as hepatotoxicity, nephrotoxicity and post-transplant hyperglycemia. Inter individual variation has necessitated frequent monitoring of tacrolimus concentration to prevent toxicity, which is the major clinical challenge encountered in the post-transplant period. This study was carried out with the aim to evaluate the correlation between blood concentration of tacrolimus and the risk/degree of toxicity with time after liver transplant. Our data suggests that monitoring effective immunosuppression is essential to minimize toxicity induced by tacrolimus, especially in the 3-6 month period. Therefore, it is necessary to maintain trough blood concentration in liver transplant recipient's 10-12 ng/ml in first trimester, 8-10 ng/ml in next trimester and 5-8 ng/ml thereafter. Hence, monitoring of tacrolimus concentration of the recipient should be done throughout the period of tacrolimus intake i.e. for life time, to enhance clinical evaluation. PARVEEN POPLI AND PRANAV KUMAR PRABHAKAR Tacrolimus, Immunosuppression, Transplant, Liver, Hepatotoxicity 191-198