10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 2 2015 (April - June) The methanolic extract of lessThan i greaterThan Nepeta granatensis lessThan /i greaterThan , were evaluated for the acute toxicity and peripheral and central analgesic activity. Female mice (Iops Offa) were treated with the methanolic extract and had shown a LD lessThan sub greaterThan 50 lessThan /sub greaterThan as 1000 mg/kg Effects of the methanolic extract, on nociception were assessed, by Tail Flick test in rats, as well, acetic acid inducing writhing in mice. The administration of the methanolic extract, intraperitoneally, at the doses 25 and 50 mg/kg, indicates that methanolic extract exhibit a power protection, against writhing (90, 9%) at the higher dose. Furthermore, reflex time; in Tail Flick exceeds the threshold of pain inhibition, that reached 11,2 ± 0,33s for the dose 50mg/kg.The in vivo experiments revealed that, methanolic extract of lessThan i greaterThan Nepeta granatensis lessThan /i greaterThan has a high potential peripheral analgesic activity and a central morphine-like either at dose 50mg/kg. BOUCHRA RAHMOUNI, KATIM ALAOUI, EL HOUCINE BOUIDIDA, MALIKA CHAMMACHE, HAMID KHAMAR, YAHIA CHERRAH AND ABDELKADER IL IDRISSI Methanolic extract, Analgesic activity, Toxicity, Nepeta granatensis. 73-80