International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 5 Issue 4
2014 (October - December)
A STUDY ON THE SYNTHESIS AND BIOCIDAL EFFICACY OF CERTAIN RANDOM COPOLYESTERS CONTAINING CHALCONE MOIETY
A series of four random copolyesters were synthesized by the polycondensation of a chalcone diol by making use of two diacid chlorides namely lessThan i greaterThan lessThan em greaterThan terephthaloyl chloride lessThan /i greaterThan lessThan /em greaterThan and succinyl chloride. The four chalcone diols involved are ( lessThan i greaterThan 2E lessThan /i greaterThan )-1,3-bis(4-hydroxyphenyl)-prop-2-en-1-one, ( lessThan i greaterThan 2E lessThan /i greaterThan )-1-(4-hydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-prop-2-en-1-one, ( lessThan i greaterThan 2E lessThan /i greaterThan )-1-(4-hydroxy-3-methoxyphenyl)-3-(4-hydroxyphenyl)-prop-2-en-1-one and ( lessThan i greaterThan 2E lessThan /i greaterThan )-1,3-bis(4-hydroxy-3-methoxyphenyl)-prop-2-en-1-one were synthesized by acid catalyzed Claisen-Schmidt reaction. These copolyesters were characterized by qualitative solubility tests and viscosity measurements. The microstructure of the repeating units available in the copolyester main chain was established by FT-IR, lessThan sup greaterThan 1 lessThan /sup greaterThan H-NMR and lessThan sup greaterThan 13 lessThan /sup greaterThan C-NMR analytical techniques. The inhibitory activity of these random copolyesters against certain bacteria and fungi is well documented. Hence, these random copolyesters may emerge as antimicrobial agents.
S. JASMINE FRANCIS , D. REUBEN JONATHAN AND D. ROOPSINGH
Chalcone, Random copolyesters, Polycondensation, Bactericidal, Fungicidal.
589-596