10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 4 2014 (October - December) Enteric fever prevails as a major public health problem despite the use of antimicrobials due to the emergence of drug resistance. The present study was undertaken to find out the antimicrobial susceptibility pattern of lessThan i greaterThan Salmonella lessThan /i greaterThan isolates from our region. Antimicrobial susceptibility testing for six drugs chloramphenicol (30µg), amoxicillin (10µg), cotrimoxazole (1.25/23.75µg), nalidixic acid (30µg), ciprofloxacin (5µg), and ceftriaxone (30µg) was done by the Kirby Bauer disc diffusion method. E-test was performed to calculate the MIC of ciprofloxacin. A total of the 80 lessThan i greaterThan Salmonella lessThan /i greaterThan species was isolated which comprised of 51 (63.8%) lessThan i greaterThan Salmonella enterica lessThan /i greaterThan serovar Typhi and 29 (36.2%) lessThan i greaterThan Salmonella enterica lessThan /i greaterThan serovar Paratyphi A lessThan i greaterThan . lessThan /i greaterThan All the isolates were nearly susceptible to the first line drugs, and none was multi drug resistant.Nalidixic acid resistance was high being 96% in lessThan i greaterThan Salmonella typhi lessThan /i greaterThan and 100% in lessThan i greaterThan Salmonella paratyphi lessThan /i greaterThan A. In lessThan i greaterThan Salmonella typhi lessThan /i greaterThan 17.6% isolates were resistant to ciprofloxacin by the disc diffusion technique whereas 47% were resistant by the E-test. Similarly in lessThan i greaterThan  Salmonella paratyphi lessThan /i greaterThan A 48.3% were detected resistant by the E- test. Reduced susceptibility to ciprofloxacin indicating higher MIC to ciprofloxacin was seen in 49 % isolates of lessThan i greaterThan Salmonella typhi lessThan /i greaterThan and 51.7% in the other serotype. These isolates are undetected by the routine disc diffusion techniques and result in treatment failure cases. It is pertinent to mention that MIC of ciprofloxacin by the E-test is more beneficial to assess the true pattern of resistance. SURUCHI BHAGRA , ANIL KANGA , SUNITE A GANJU AND ATAL SOOD Multidrug resistance, Salmonella enterica serovar Typhi, Salmonella enterica serovar Paratyphi A, nalidixic acid, ciprofloxacin, ceftriaxone 01-09