International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 5 Issue 4
2014 (October - December)
SYNTHESIS, REPRECIPITATION METHOD AND PHARMACOLOGICAL POTENCY OF FREE PORPHYRIN BASED NANOPARTICLES
We have designed and synthesized a new symmetrical porphyrins 3a-d and their nanoparticles based on extended lessThan i greaterThan π lessThan /i greaterThan -conjugation concept. The new sensitizers were fully characterized by CHN analysis, UV-Vis., lessThan sup greaterThan 1 lessThan /sup greaterThan H-NMR, TEM and Mass spectroscopy. The new sensitizers and their nanoparticles were evaluated as antitumor activity against HepG2, WI-38, VERO and MCF-7 cell lines. It was found that porphyrin nanoparticles have the most potent activity.
RASHA E. EL-MEKAWY AND SRAA ABU-MELHA
Pyrrole, Porphyrin, porphyrin nanoparticles, Antitumor activity
501-515