10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 3 2014 (July- September) In the present study, the free radical scavenging activity of fresh and dry rhizomes of lessThan i greaterThan Curcuma longa lessThan /i greaterThan was compared. The fresh and dry rhizomes of lessThan i greaterThan Curcuma longa lessThan /i greaterThan were serially extracted into different solvents (petroleum ether, benzene, chloroform, ethyl acetate, methanol and water) of increasing polarity using a Soxhlet apparatus. The free radical quenching activity of the extracts were characterized against a battery of free radicals such as DPPH (1,1'-diphenyl-2-picryl hydrazyl), H lessThan sub greaterThan 2 lessThan /sub greaterThan O lessThan sub greaterThan 2 lessThan /sub greaterThan (hydrogen peroxide), ABTS (2,2'-azino-bis-3-ethyl benzthiazoline-6-sulphonic acid), SO (superoxide), NO (nitric oxide) and OH lessThan sup greaterThan ● lessThan /sup greaterThan (hydroxyl), generated lessThan i greaterThan in vitro. lessThan /i greaterThan The results obtained in the present study indicate that both fresh and dry rhizomes of lessThan i greaterThan Curcuma longa lessThan /i greaterThan are more potent in scavenging free radicals in an effective way at a concentration of 10µg/ml. MANOHARAN MOHANA AND PALGHAT RAGHUNATHAN PADMA Free radical scavenging - extracts - fresh and dry rhizomes - Curcuma longa. 673-681