10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 3 2014 (July- September) Uncontrolled Diabetes Mellitus Causes both microangiopathy leading to diabetic nephropathy & retinopathy and macroangiopathy leading to coronary heart diseases & also diabetic neuropathy. Hypertension itself is characterized by arteriosclerosis. To assess the coagulation status, we measured PT & APTT in these cases. A 52 Known Type II diabetic patients with hypertension, 32 known Type II Diabetes Mellitus patients & 30 controls were included in the study. Both PT & APTT were measured on CA-50 Sysmex Coagulation Analyzer. The FBS & PPBS were estimated on Humastar-300 complete Auto analyzer. BMI was calculated for all the subjects. The PT was prolonged in Group B (14.86538 + 0.12290 ) than controls (13.83333 + 0.08419) ,p = 0.0000001 and Group A(13.40 + 1.29) ,p = 0.0000001. The APTT was prolonged in Group B (34.53846 + 0.27933 ) than controls (30.13333 + 0.32424) p = 0.0000001 and Group A(30.81 + 2.40) ,p = 0.0000001 respectively. The FBS was increased in cases than controls ( p = 0.0000001 ). The PPBS was also increased in cases than controls ( p = 0.0000001). The BMI for Group A (26.55 + 3.2) Group B (26.9615 + 2.6515) and for controls (25.05 + 2.7268). This study showed Prolonged PT and APTT in diabetes mellitus with hypertension. Abnormal PT & APTT are the indications of altered activity or absence or decreased levels of clotting factors of intrinsic & extrinsic coagulation pathways respectively. The BMI value indicates that cases are overweight. PT & APTT should be checked in such cases prior to any surgery. P.KRISHNA CHAITANYA, SUCHITRA KAVURI AND K.AMBIKA DEVI Procoagulant, Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), Tissue Factor, Fibrinolysis. 705-709