10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 3 2014 (July- September) Diabetes is a chronic metabolic disorder characterized by high blood glucose level in the body due to alteration in carbohydrate metabolism. Prevalence of diabetes is expected to cross 123 million by 2035. Two enzymes, α-amylase and α-glucosidase play a major role in starch digestion. Inhibition of these enzymes results in significant reduction of type 2 diabetes. The plant, lessThan i greaterThan Mentha longifolia lessThan /i greaterThan possess good medicinal values such as, antimicrobial and antioxidant property. It can also be used as an antidiabetic agent. In order to test this hypothesis, the phytochemical constituent of lessThan i greaterThan Mentha longifolia lessThan /i greaterThan was obtained from the previous literature study. lessThan i greaterThan In silico lessThan /i greaterThan docking study was carried out for all the phytochemical against α-amylase and α-glucosidase. Trans-piperitol and menthol are found to be the top two compounds with good binding energy S SANTHOSH Diabetes, Mentha longifolia, α-amylase, α-glucosidase, Trans-piperitol and menthol. 601-606