10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 3 2014 (July- September) Diabetes Mellitus is the most common of the endocrine disorders. Diabetes patients have significant defects of Anti-oxidant protection, which may enhance their susceptibility to oxidative damage and development of diabetic complications. The present study comprised of estimation of the biochemical parameters and two special investigations i.e. Serum Malondialdehyde and Blood Glutathione levels in sixty cases [20 normal healthy individuals and 40 N.I.D.D.M. patients] attending the outpatient department of Goa Medical College. Serum Malondialdehyde and Blood GSH levels were significantly increased along with Serum Uric acid, Serum total Cholesterol, Triglycerides, LDL and VLDL-Cholesterol as compared to apparently healthy individuals. HDL-Cholesterol levels were significantly decreased CARLOS NOEL MENEZES AND CHITRA Y DHUME Diabetes Mellitus, Malondialdehyde and Blood Glutathione 583-589