10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 3 2014 (July- September) The present study was taken up to evaluate the efficacy of lessThan i greaterThan Trigonella lessThan /i greaterThan lessThan i greaterThan foenum graecum lessThan /i greaterThan and lessThan i greaterThan Coccinia indica lessThan /i greaterThan individualy and in combination in streptozotocin induced diabetic rats for a period of 90 days. The various groups in this study included normal control (Group-I), diabetic control (Group-II), diabetic rats treated with lessThan i greaterThan Trigonella foenum graecum lessThan /i greaterThan (Group-III), diabetic rats treated with lessThan i greaterThan Coccinia indica lessThan /i greaterThan (Group-IV), diabetic rats treated with lessThan i greaterThan Trigonella foenum graecum lessThan /i greaterThan and lessThan i greaterThan Coccinia indica lessThan /i greaterThan (Group-V) respectively. There was significant variation in biochemical and pathomorphological parameters of diabetic rats when compared to normal control rats. The alleviation of the diabetic and its complications induced by streptozotocin was observed in all the treatment groups with variable degree of improvement. lessThan i greaterThan Trigonella lessThan /i greaterThan lessThan i greaterThan foenum graecum lessThan /i greaterThan and lessThan i greaterThan Coccinia indica lessThan /i greaterThan extracts were effective in alleviating streptozotocin induced diabetes. Combination of lessThan i greaterThan Trigonella lessThan /i greaterThan lessThan i greaterThan foenum graecum lessThan /i greaterThan and lessThan i greaterThan Coccinia indica lessThan /i greaterThan showed better improvement compared to individual extract alone and improvement was statistically significant. However the combined treatment of lessThan i greaterThan Trigonella foenum graecum lessThan /i greaterThan and lessThan i greaterThan Coccinia indica lessThan /i greaterThan revealed a very good antidiabetic effect with reference to improvement in insulin level and beta cell number which indicated a synergistic effect between lessThan i greaterThan Trigonella lessThan /i greaterThan lessThan i greaterThan foenum graecum lessThan /i greaterThan and lessThan i greaterThan Coccinia indica lessThan /i greaterThan SHESHA RAO, SUGUNA RAO AND SHETTAR M Diabetes, Coccinia indica, Trigonella foenum graecum Streptozotocin, 136-144