10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 3 2014 (July- September) Coronary heart disease (CHD) has become the most important cause of premature morbidity and mortality. The chief risk factors for CHD includes Smoking, Hypertension, Diabetes mellitus, Hypercholesterolemia, Low high density lipoprotein, Obesity, Mental stress, Type A personality and Genetic factors. Lipoprotein (a) has been established as a strong independent risk factor for premature CHD, which is highly thrombogenic and antifibrinolytic which begins to block the arteries much earlier than other risk factors. Free radicals can cause metabolic disturbances and cell injury, damage cardiovascular system by atherosclerosis and ischaemia reperfusion. Increased oxidative stress may result from over production of precursors to reactive oxygen radicals and / or decreased efficiency of inhibitory and scavenger systems. Antioxidant functions as blockers of radical processes before they can damage various biomolecules or prevent oxidative damage from spreading out the effect. The present study comprises of 80 patients, 20 patients of myocardial infarction, 60 patients with risk factor of Coronary heart disease (CHD), including Hypertension, Diabetes mellitus, Smoking and Obesity. 20 healthy age and sex matched subjects served as controls. All the patients in the study group and control group were aged between 30-60 years. This study is planned to determine the antioxidant status and to estimate Serum lipoprotein (a) levels in patients of CHD and in patients with risk factors for CHD. Study comprised of estimation of Biochemical parameters like serum Lipoprotein(a), serum Malondialdehyde (M.D.A.), Blood Glutathione, Serum Vitamin E, Plasma Vitamin C and Plasma Vitamin A (special ones) with routine parameters like Blood Glucose, Serum Cholesterol, Serum Triglycerides, Serum HDL, Serum LDL, Serum VLDL, TC/HDL, LDL/HDL ratio. DR. SUDEEP R.LOKAPURE,DR. J. N. ZORE2 AND DR. CHITRA Y. DHUME Coronary heart disease, Lipoprotein (a), MDA , Antioxidants. 359-367