10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 3 2014 (July- September) An efficient synthesis of series of different novel lessThan i greaterThan β lessThan /i greaterThan -lactams via cycloaddition reaction (Staudinger reaction) of Schiff base has been reported in the present communication. A series of newly substituted 8-hydroxyquinoline Schiff base derivatives have been synthesized efficiently following Betti's condensation protocol with 8-hydroxyquinoline and different aldehydes under ambient reaction conditions. The structures of the newly synthesized Schiff base derivatives and lessThan i greaterThan β lessThan /i greaterThan -lactams were confirmed by IR, lessThan sup greaterThan 1 lessThan /sup greaterThan H NMR, elemental analysis and mass spectroscopic data. In-vitro anti-bacterial evaluations of β-lactams were done against gram-positive and gram-negative bacterial strains using the well diffusion method. It has been observed that some of these derivatives posses potent anti-bacterial characteristics against these bacteria. HIMANI N. CHOPDE Azetidinone, 8-hydroxyquinoline, betti’s condensation, staudinger reaction, schiff’s base, anti-bacterial activity. 541-548