10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 3 2014 (July- September) lessThan i greaterThan In vitro lessThan /i greaterThan and lessThan i greaterThan in vivo lessThan /i greaterThan antiinflammatory activities of methanolic extract of white oyster mushroom lessThan i greaterThan Pleurotus florida lessThan /i greaterThan (Mont.) Singer were evaluated. The mushroom extract exhibited significant results for its inhibition of protein denaturation (69.30±4.98% at 1.0mg/ml); inhibition of proteinase activity (27.89±0.14% at 1.0mg/ml) in a dose-dependent manner and also antiinflammatory activity in Carrageenan induced acute inflammatory animal model (50.17% at 200mg/kg b.w). Presence of phytochemicals namely phenols, flavonoids, saponins and tannins may be responsible for such antiinflammatory activity. Results indicate that, white oyster mushroom may be used as a potential antiinflammatory agent. MADHAIYAN PRABU AND RENGANATHAN KUMUTHAKALAVALLI Pleurotus florida, antiinflammatory activity, methanolic extract, phytochemicals, phenols, flavonoids. 370-375