International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 5 Issue 3
2014 (July- September)
EFFECT OF VOGLIBOSE ON LIPID PROFILE IN ALLOXAN-INDUCED DIABETIC RABBITS WITH TYPE-II DIABETES MELLITUS AND DYSLIPIDEMIA.
Diabetes is an iceberg disease. There is an increase in the prevalence and incidence of Type-II DM globally. It is an incurable metabolic disorder. Diabetes mellitus always regarded primarily as a disturbance of carbohydrate metabolism. It is the last few decades that the disturbances in lipid metabolism has been described in association with Type II DM. Diabetes is a syndrome characterized by chronic hyperglycemia and disturbance of carbohydrate, lipid, and protein metabolism. There are several reports showing that hyperglycemia and hyperlipidemia are associated with increased cardiovascular risks.Alfaglucosidase inhibitors like acarbose,voglibose and miglitol inhibits the action of enzyme alfaglucosidase and reduces post prandial hyperglycemia on chronic use. As voglibose decreases post prandial hyperglycemia it spares beta cells of the pancrease and decreases the progress of the disease and also decreases insulin resistance.36 rabbits were induced diabetic by administering alloxan I.V. in the marginal ear vein of rabbits. Doses of alloxan required to induce diabetic according to kg body wt of the rabbits as reference table. Voglibose was found to be statistically significant than control group lipid profile at 8 lessThan sup greaterThan th lessThan /sup greaterThan week of treatment (p
MANAS RANJAN NAIK, RATNA PALIT, DIVYA AGRAWAL, KARMAJEET RATH, SANJAY KUMAR AND SUDHANSHU S MISHRA
α-glucosidase inhibitors, voglibose, alloxan.
259-267