International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 5 Issue 3
2014 (July- September)
EVALUATION OF ANTIBACTERIAL AND ANTITUBERCULAR ACTIVITY OF PHASEOLUS VULGARIS LINN., SEEDS
Due to the increasing emergence of drug resistant Tuberculosis (TB), particularly multi-drug resistant TB (MDR-TB), extensive-drug resistant TB (XDR-TB) and also the development of resistance in the micro-organisms against available drugs there is a need to develop new, potent, fast-acting antibacterial and antitubercular drugs with low toxicity. With this aim different extracts of lessThan i greaterThan Phaseolus vulgaris (Linn) lessThan /i greaterThan seeds were evaluated for antibacterial and antitubercular activities using ciprofloxacin, norfloxacin and isoniazid as standard drugs, respectively. The alcoholic extract showed significant activity against lessThan i greaterThan Streptococcus faecalis lessThan /i greaterThan and lessThan i greaterThan Escherichia coli lessThan /i greaterThan . Petroleum ether extract has shown significant antitubercular activity against lessThan i greaterThan M. tuberculosis lessThan /i greaterThan strain H lessThan sub greaterThan 37 lessThan /sub greaterThan Rv and lessThan i greaterThan Escherichia coli lessThan /i greaterThan . The alcoholic and petroleum ether extracts can be considered as a potential candidate for antibacterial and antitubercular activity. The presence of alkaloids in alcoholic extract and steroids, flavonoids in the petroleum ether extract of lessThan i greaterThan Phaseolus vulgaris (Linn) lessThan /i greaterThan seeds could be attributed for the antibacterial and antitubercular activities.
M. R. PRADEEP KUMAR, SHRINIVAS .D. JOSHI2 AND V.H. KULKARNI
Antibacterial, Antitubercular, Phaseolus vulgaris (Linn) seeds, M. tuberculosis strain H37Rv.
219-224