10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 3 2014 (July- September) Objective of this work is to study the antinociceptive activity of haloperidol, metoprolol, metoclopramide, venlafaxine and their interactions with tramadol and diclofenac. Antinociceptive action of haloperidol (1, 2 mg/kg), metoprolol (3, 5 mg/kg), metoclopramide (2, 5 mg/kg) and venlafaxine (5, 10 mg/kg) were studied in rats (tail flick and tail immersion tests). The sub-analgesic doses of haloperidol, metoprolol, metoclopramide and venlafaxine were combined with sub-analgesic doses of tramadol, diclofenac to further study their antinociceptive effects. The antinociceptive action of test drugs were found only at higher doses, for haloperidol (2 mg/kg), metoprolol (5 mg/kg), metoclopramide (5 mg/kg) and venlafaxine (10 mg/kg); that was statistically significant. When a sub-analgesic dose of test drugs were combined with sub-analgesic doses of tramadol, diclofenac, the combination resulted in a significant antinociceptive effect.Observations from our study indicate that various non-analgesic drugs may prove as alternative strategies for pain management in practice; possibly for adjuvant use. DR. RAJANISH KUMAR SANKDIA AND DR. SHILPA N. KAORE Antinociceptive activity, tail flick method, tail immersion test 79-90