10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 1 2014 (January - March) Ranitidine is a well known drug and sold over the counter all over the world, it was the most popular drug from 1981 to 1988 and used regularly in today's practice. It is well tolerated and with negligible side effects. This case report illustrates a sudden cardiac depression after the single intravenous dose of 50 mg ranitidine due to which patient had a sudden cardiac arrest.Patient lessThan b greaterThan - lessThan /b greaterThan A 32 year old female, who was to be operated for Hemithyroidectomy, was given intravenous ranitidine pre operatively, she went on to develop sudden cardiac depression and cardiac arrest.Despite initial resuscitative efforts and intensive care, patient developed supra ventricular tachycardia day after the attack and succumbed to cardio respiratory arrest.While administering in the intravenous form, adverse drug reaction in the form of sudden cardiac depression with ranitidine is very rare but it should always be remembered, as knowledge about this drug can prevent the future co morbidities. DR RITESH MAHAJAN , DR NAGARAJ TM , DR PRAVEEN KUMAR , DR SHIVANAGOUDA PATIL AND DR ROSHNA MOYIN Rantac, Adverse drug reaction, sudden cardiac arrest 1043-1045