10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 1 2014 (January - March) Chronic kidney disease is a worldwide public health problem and now recognized as a common condition that is associated with an increased risk of cardiovascular disease. The study was designed to assess the status of thyroid hormones which is of great value in determining the prognosis of patients in chronic renal failure.60 cases and 40 healthy subjects (controls) were included in the study after taking informed consent. In all these subjects serum concentration of urea, creatinine, freeT lessThan sub greaterThan 3 lessThan /sub greaterThan , free T lessThan sub greaterThan 4 lessThan /sub greaterThan and TSH were measured. Serum level of urea, creatinine were significantly increased. There was significant reduction in serum free T lessThan sub greaterThan 3 lessThan /sub greaterThan and freeT lessThan sub greaterThan 4 lessThan /sub greaterThan in cases as compared to controls (p lessThan 0.0001). There was no significant increase in serum level of TSH in cases as compared to controls (p =0.1323). From this study it was observed that chronic renal failure is associated with low thyroid function which is a risk factor for cardiovascular disease. DR. SMITA PADHY AND DR. K. AMBIKA DEVI Chronic renal Failure, Free T3 , Free T4 , TSH 171-175