POTENT IN-VITRO ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF PYRANO[2,3-D]PYRIMIDINE DERIVATIVES WITH QUANTITATIVE YIELD

10.22376/ijpbs.2019.10.1.p1-12

Volume 5 Issue 1 2014 (January - March) POTENT IN-VITRO ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF PYRANO[2,3-D]PYRIMIDINE DERIVATIVES WITH QUANTITATIVE YIELD A series of Pyrano[2,3-d]Pyrimidine derivatives were synthesis using Knoevenagel and Michael addition reaction. Investigation of antimicrobial properties were done against gram positive bacteria Staphylococcus(NCTC-7447),Bacillus cereus(ATCC-14579) and gram negative bacteria Serratia maresens(IMRU-70), Proteus merabitis (NTCC-289) using Ampicillin as standard drugs. These synthesized compounds were also screened for their antifungal activity against two species of fungi Aspergillus ochraceus Wilhelm (AUCC-230 and Penicillium chrysogenum thom (AUCC-530) using Mycostatin as standard drugs. All the tested compounds shown moderate activity. The structures of the synthesized compounds were elucidated by spectral analysis (IR, 1HNMR and 13CNMR). AJMAL R. BHAT, RAJENDRA S. DONGRE AND RUPALI S.SELOKAR Pyrano[2,3-d]Pyrimidine derivatives, Ethylcyanoacetate, barbituric acid, aromatic aldehydes, N-base Triethylamine, Biological activity. 422-430