10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 1 2014 (January - March) Tuberculosis has been a serious public health problem for a long time. With the advent of anti-tubercular antibiotics in the late 1940s, the battle against tuberculosis seemed to have been won but the multi-drug resistance; re-infection and latent infection have become the major cause of concern for the treatment of tuberculosis all over the world. In the present study derivatives of Plumbagin, obtained from lessThan i greaterThan Plumbago zeylanica lessThan /i greaterThan (Family- lessThan i greaterThan Plumbaginaceae lessThan /i greaterThan ) have been synthesized. Out of the various analogs synthesized, the antitubercular activity of compound 1,2 and 3 was evaluated using standard H lessThan sub greaterThan 37 lessThan /sub greaterThan Rv and S,H,R and E sensitive lessThan i greaterThan M. tuberculosis lessThan /i greaterThan strains using LRF assay method. Compound 1 showed strongest activity against both standard H lessThan sub greaterThan 37 lessThan /sub greaterThan Rv and S,H,R and E sensitive lessThan i greaterThan M. tuberculosis lessThan /i greaterThan strains as compared to standard Rifampicin. The other compounds are proved to be more active against standard H lessThan sub greaterThan 37 lessThan /sub greaterThan Rv and S,H,R and E sensitive lessThan i greaterThan M.tuberculosis lessThan /i greaterThan strain as compared to Rifampicin. NISHI NAYAK , MEENAKSHI BAJPAI AND BALKISHEN RAZDAN Plumbagin, Streptomycin(S), Isoniazid(H), Rifampicin(R),Ethambutol(R) 388-395