10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 1 2014 (January - March) lessThan i greaterThan Picrorrhiza kurroa lessThan /i greaterThan (Scrophulariaceae) is a small perennial herb growing in the hilly parts of the north-Western Himalayas region in India and Nepal. The objective of the present study was to evaluate and compare antipyretic activity of lessThan i greaterThan Picrorrhiza kurroa lessThan /i greaterThan royle ex. Benth by using 2, 4-Dinitro Phenol (DNP), D-Amphetamine and brewer's Yeast induced pyrexia models. Paracetamol was used as the standard drug to compare the test results. The test extract showed significant antipyretic activity (p lessThan 0.05) which justify its use in ethnomedicine. A.RAJANI , M.SWATHI , M.MADHURI , SK.ARIFA BEGUM , M.VISHNU VARDHAN REDDY AND K.HEMAMALINI Picrorrhiza kurroa, antipyretic activity, 2, 4-Dinitro Phenol, D-Amphetamine, brewer’s Yeast induced pyrexia, Paracetamol. 340-343