10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 1 2014 (January - March) The present study was conducted to evaluate the lessThan i greaterThan in vitro lessThan /i greaterThan anti-cataract potential of lessThan i greaterThan Tinospora cordifolia (Tc) lessThan /i greaterThan and lessThan i greaterThan Phyllanthus emblica (Pe) lessThan /i greaterThan . Aldose Reductase Inhibitory (ARI) activity was evaluated using the method of Kinoshita lessThan i greaterThan et al. lessThan /i greaterThan Only that concentration of plant extracts demonstrating maximum ARI activity was evaluated for anti-cataract and anti-oxidant potential using an lessThan i greaterThan in vitro lessThan /i greaterThan sugar induced cataracteric lens organ culture model. Lens parameters evaluated included morphological variation, aldose reductase (AR) activity, Total Protein content and anti-oxidant enzymes lessThan i greaterThan viz., lessThan /i greaterThan catalase and Superoxide Dismutase. Quercetin, a pure flavonoid was used as a positive control. Both lessThan i greaterThan Tc lessThan /i greaterThan and lessThan i greaterThan Pe lessThan /i greaterThan demonstrated dose dependent inhibition of AR with maximum activity at 100µg/ml. Loss of lens transparency, increased AR activity, decrease in soluble and total protein content was observed in diabetic lenses as compared to normal lenses. The diabetic conditions augmented anti-oxidant enzymes indicating oxidative stress. Supplementation with lessThan i greaterThan Tc lessThan /i greaterThan & lessThan i greaterThan Pe lessThan /i greaterThan decreased AR levels, increased levels of total and soluble proteins significantly with a decrease in catalase and superoxide dismutase. These results were comparable to quercetin. The results suggest that these plants have the potential to arrest the progression of cataract which is mediated by their anti-oxidant activity. KALEKAR SA, MUNSHI RP AND KULKARNI DK Aldose Reductase, Cataract, Catalase, Superoxide dismutase, anti-oxidant, Phyllanthus emblica, Tinospora cordifolia 120-130