10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 1 2014 (January - March) Diabetes is a metabolic disorder which results due to deficiency in insulin and its metabolism. A search for effective medication with lesser or no side effects is the need of the hour. Hence the current study is focused at evaluating the anti-diabetic potential of lessThan i greaterThan Grewia hirsuta. lessThan /i greaterThan The leaves of lessThan i greaterThan G. hirsuta lessThan /i greaterThan were subjected to solvent extraction with methanol, ethyl acetate and hexane and analyzed by various lessThan i greaterThan in vitro lessThan /i greaterThan assays such as inhibition of carbohydrate digesting enzymes, non-enzymatic glycosylation of hemoglobin, glucose diffusion and uptake of glucose by yeast cells. The best screened extract was further evaluated for it phytochemical profile by qualitative and quantitative phytochemical analysis. The extract was also subjected to TLC. The results of the study suggest that lessThan i greaterThan Grewia hirsuta lessThan /i greaterThan possesses significant hypoglycemic potential. With further mechanistic studies it can be proved as a better source of natural anti-diabetic agents. N.ABIRAMI, B.NATARAJAN AND E.SAGADEVAN Grewia hirsuta, anti-diabetic activity, phytochemical analysis, thin layer chromatography. 76-83