10.22376/ijpbs.2019.10.1.p1-12 Volume 5 Issue 1 2014 (January - March) The plant lessThan i greaterThan Caralluma adscendens var. adscendens lessThan /i greaterThan belongs to Asclepiadaceae family was taken for the evaluation of anti-diabetic and anti-inflammatory activity. Diabetes mellitus is a chronic disorder characterized by hyperglycemia with a disturbance of carbohydrate, protein and fat metabolism. Phytochemical screening of lessThan i greaterThan C. adscendens lessThan /i greaterThan extract indicated the presence of several bioactive compounds like alkaloids, saponins, tannins, steroids, terpenoids, flavonoids and proteins. Anti-diabetic study was carried out by using the butanone extract and investigated using alloxan induced diabetic rats. The oral administration of extract at dose 500 mg/kg led to a significant blood glucose reduction. The anti-inflammatory activity of lessThan i greaterThan C. adscendens lessThan /i greaterThan against carrageenan induced paw edema in albino rats was also carried out. The anti-inflammatory activity is more effective in carrageenan induction with oral administration of lessThan i greaterThan C. adscendens lessThan /i greaterThan extract at dose 500 mg/kg body weight and the study was compared with standard drug Indomethacin (10mg/kg). The results showed that lessThan i greaterThan C. adscendens lessThan /i greaterThan is having significant anti-diabetic and anti-inflammatory activity. BHUVANESWARI S AND MANIVANNAN S Caralluma adscendens, Diabetes mellitus, Hyperglycemia, Phytochemistry, Anti-inflammatory activity 42-49