10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) The present study evaluated the free radical scavenging capacity and antioxidant potential of different solvent fractions (Petroleum ether, Ethyl acetate, Butanol and Water) of methanolic extract of lessThan i greaterThan Cissus quadrangularis lessThan /i greaterThan stem. Ethyl acetate fraction of lessThan i greaterThan Cissus quadrangularis lessThan /i greaterThan stem possessed a high amount of total phenolic and flavonoid contents as compared to other solvent fractions. Also Ethyl acetate fraction exhibited maximum scavenging activity against DPPH (IC lessThan sub greaterThan 50 lessThan /sub greaterThan 62.53±5.71μg/ml), superoxide (IC lessThan sub greaterThan 50 lessThan /sub greaterThan 50.7±4.86μg/ml), hydroxyl (IC lessThan sub greaterThan 50 lessThan /sub greaterThan 24.38±2.34μg/ml) and nitric oxide radicals (IC lessThan sub greaterThan 50 lessThan /sub greaterThan 33.83± 3.09μg/ml). These fractions were also screened for their antidiabetic activity via antiglycation assay. Results showed that the ethyl acetate fraction exhibited higher antiglycation activity. Significant antiglycation activity also confirms the therapeutic potential of these fractions against diabetes. R.K.LEKSHMI AND S. MINI Free radicals, Ethyl acetate fraction, Antioxidant, Antiglycation, Phenolics 1259-1268