10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) A Simple and convenient protocol is described for preparation of some new 5-(2'-hydroxy-3',5'-dichlorophenyl)-4-(4'-chlorobenzyl)-2-amino-1,3-thiazole and 5-(2'-hydroxy-3',5'-dichlorophenyl)-4-(4'-chlorobenzyl)-2-aminophenyl-1,3-thiazole, were synthesized by refluxing dibrominated chalcone with thiourea or N-phenyl thiourea in good yields. The newly synthesized titled compounds were screened for their antibacterial activities against pathogens such as lessThan i greaterThan staphylococcus aureus lessThan /i greaterThan , lessThan i greaterThan p.aeruginosa lessThan /i greaterThan , lessThan i greaterThan salmonella typhi lessThan /i greaterThan . Some of the compounds displayed pronounced biological activity. All these compounds have been characterized on the basis of their UV, IR and NMR spectral results. A V GAJBHIYE AND P R RAJPUT Thiazoles, antibacterial activities, chalcone, thiourea, phenyl thiourea. 899-903