10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) In this study, the effect of lessThan i greaterThan Emblica officinalis lessThan /i greaterThan and lessThan i greaterThan Solanum nigrum lessThan /i greaterThan fruit extracts against H lessThan sub greaterThan 2 lessThan /sub greaterThan O lessThan sub greaterThan 2 lessThan /sub greaterThan induced oxidative stress in lessThan i greaterThan Saccharomyces cerevisiae lessThan /i greaterThan was analyzed using vitamin E as standard. GC-MS analysis of ethanolic extract of lessThan i greaterThan S.nigrum lessThan /i greaterThan and lessThan i greaterThan E.officinalis lessThan /i greaterThan fruits revealed the presence of 51 and 25 phytoconstituents respectively. lessThan i greaterThan S.cerevisiae lessThan /i greaterThan cells cultured in YEPD medium were divided into eight groups of 1X10 lessThan sup greaterThan 6 lessThan /sup greaterThan cells / ml each. The groups pre-treated with plant extract were subjected to oxidative stress by H lessThan sub greaterThan 2 lessThan /sub greaterThan O lessThan sub greaterThan 2. lessThan /sub greaterThan Decreased apoptosis was observed with the yeast cells treated with fruit extract as compared with the cells treated with H lessThan sub greaterThan 2 lessThan /sub greaterThan O lessThan sub greaterThan 2 lessThan /sub greaterThan alone. Antioxidant nature of the fruit extracts was determined by assessing SOD and catalase activity in yeast cells. The level of protein, SOD and catalase activity showed significant increase in yeast cells treated with plant extract than H lessThan sub greaterThan 2 lessThan /sub greaterThan O lessThan sub greaterThan 2 lessThan /sub greaterThan treated cells. These extracts also protected the cells, its protein and other biomolecules from the oxidative damage, thereby increased the cell viability and stability. The protective mechanism may be due to the phytoconstituents with antioxidant nature and hence these plant fruits could be used as an alternate as therapeutic agents in free radical mediated diseases. NAGESHWARI KRISHNAMURTHY, MANI ARUNKUMAR, BALAKUMAR SRINIVASAN AND SIVAKUMAR RAMALAINGAM S.nigrum, E.officinalis, S.cerevisiae and phytoconstituents. 370-380