10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) The present study investigates chronotherapeutic effects of renal markers and lipid peroxidation and antioxidant properties in nephrotoxic rats, adult male albino Wistar rats, weighing 180-200 g with a nephrotoxic dose of vancomycin (200 mg/kg/body weight, twice a day(12 hour interval), i.p injection). This study used rats that were treated with 7 groups especially treatment group (GA + VAN) divided in to 4 groups (i.e 06:00hrs, 12:00hrs, 18:00hrs, 24:00hrs). Results showed that 24:00h time point level is peak when compared with other time points. The present study demonstrates that gallic acid can be protective against vancomycin -induced nephrotoxicity. SADEESHKUMAR .V Chronotherapy, Gallic acid, Vancomycin, Nephrotoxicity, Wistar rats. 289-298