10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) The present study was carried out to evaluate the antioxidative effect of lessThan i greaterThan Aloe vera lessThan /i greaterThan ( lessThan i greaterThan A. vera lessThan /i greaterThan ) aqueous leaf extract on hepatotoxicity induced by SO lessThan sub greaterThan 2 lessThan /sub greaterThan inhalation in male albino rats. Hepatotoxicity was assessed by estimating the Serum Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Gamma Glutamyl Transferase (GGT) and histopathological changes in liver of rats. Experimental rats were exposed to 80ppm hrd-1, SO lessThan sub greaterThan 2 lessThan /sub greaterThan gas per day for 30 and 60 days. A significant increase in Serum ALP (P lessThan 0.001), AST (P lessThan 0.01), ALT (P lessThan 0.001), GGT (P lessThan 0.05) and histopathological changes include hepatocytes necrosis, degeneration of hepatocytes, centrilobular necrosis, ballooning degeneration and cellular debris have observed after SO lessThan sub greaterThan 2 lessThan /sub greaterThan exposure in comparison to control rats. A marked reduction in liver injury is reported after exposure with oral administration of lessThan i greaterThan A. vera lessThan /i greaterThan leaf extract (200mgkg-1 body weight d-1) in comparison to SO lessThan sub greaterThan 2 lessThan /sub greaterThan exposed rats. Antioxidative and anti-inflammatory properties of lessThan i greaterThan A. vera lessThan /i greaterThan shows potential to modulate the hepatocellular damage induced by SO lessThan sub greaterThan 2 lessThan /sub greaterThan gas in rats. MADHURI YADAV, ASHA AGARWAL ANDPREETI KUMARI Male albino rat, SO2, A. vera aqueous leaf extract, Liver injury 170-176