10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) Noise is a common environmental stress factor that leads to alterations in plasma catecholamine, adrenocorticotropic hormone (ACTH) and cortisol concentrations. The countries are now a day's interested in natural remedies, phytomedicines. In our present study we examined the effects of noise stress on glucocorticoid and glucose metabolism and the efficacy of ethanolic extract of lessThan i greaterThan Ocimum sanctum lessThan /i greaterThan ( lessThan i greaterThan OS lessThan /i greaterThan ) in preventing these alterations. Wistar albino male rats were divided into four groups-Groups I (Control), Group II ( lessThan i greaterThan OS lessThan /i greaterThan treated), Group III (stressed) and Group IV ( lessThan i greaterThan OS lessThan /i greaterThan pre treated and stressed). Noise stress for 15 days (100dB for 4hrs/ day) was given to the group III and IV and lessThan i greaterThan OS lessThan /i greaterThan was injected to Group II and Group IV (100 mg/ kg bw. i.p). On the 16 lessThan sup greaterThan th lessThan /sup greaterThan day, animals were sacrificed and blood samples were analyzed for various biochemical parameters. In our study, corticosterone, glucose, insulin, glycogen phosphorylase levels and adrenal/body weight ratio were found to be significantly increased in the stressed group compared to the control and the levels of liver glycogen, muscle glycogen, glycogen synthase and thymus/body weight ratio were found to significantly decrease in the stressed group compared to the control. Our study showed that these alterations could be significantly reversed by lessThan i greaterThan OS lessThan /i greaterThan . VELUSAMI DEEPIKA AND R. SHEELA DEVI Noise-stress, Glucose metabolism, Corticosterone, Ocimum sanctum. 29-39