10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) Diabetes mellitus type 2 (formerly noninsulin-dependent diabetes mellitus (NIDDM) or adult onset diabetes) is a metabolic disorder that is characterized by high blood glucose either due to insulin resistance or insulin deficiency. Using bio-informatics, human hemoglobin was targeted for docking a ligand at pre-specified regions of its three dimensional structure for Type 2 Diabetes mellitus. Wide ligand search from databases identified hyperoside as desirable ligands that docked well with protein haemoglobin. Molecular dynamics simulations were made to study the drugs-protein interactions. It was shown that RMSD (Root Mean Square Deviation) curve for haemoglobin-hyperoside complex are remarkably more stable. The results demonstrate that hyperoside might be potentially used for blood glucose regulation. M. UMA MAKHESWARI AND D. SUDARSANAM Heamoglobin, Hyperoside, RMSD curve and Molecular Dynamics 23-28