10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) lessThan i greaterThan Homo sapiens lessThan /i greaterThan and lessThan i greaterThan Mus musculus lessThan /i greaterThan genomes have the similarity ranges from 70% to 90% with an average of 85%. Interleukin (IL) has 17 different families among which interleukin 2 (IL2) is present in both lessThan i greaterThan Homo sapiens lessThan /i greaterThan and lessThan i greaterThan Mus musculus lessThan /i greaterThan . IL2 activates the receptor named IL2-R which further proliferate lymphocytes such as T-cell and B-cell. IL2 is a glycosylated polypeptide lymphokine. It requires cleavage of the signal sequence for its activity. IL2 is used for immunotherapy to treat cancer and its suppression avoids autoimmunity in patients with transplantations. IL2 of lessThan i greaterThan Homo sapiens lessThan /i greaterThan and lessThan i greaterThan Mus musculus lessThan /i greaterThan are studied and analysed using simulation and structural analysis methods. The results are compared to obtain their similarity profile. This result can further be applied in the study of inflammatory disease related aspects in future. NEHA SINGH, AKRITI JAIN AND ANAND ANBARASU Interleukin 2, Physio-chemical properties, Topology mapping, Solvent accessible area, Stabilizing Centre and Stabilizing Residue 902-909