10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) 1,5-Benzothiazepine scaffold is an important class of heterocycles and has featured in a number of clinically used drugs. Compounds bearing 1,5-benzothiazepine moiety shows a broad spectrum of biological activities such as CNS-acting agents, anti-HIV and anticancer drugs, angiotensin converting enzyme inhibitors, antimicrobial, calmodulin antagonists, bradykinin receptor agonists, as well as Ca lessThan sup greaterThan 2+ lessThan /sup greaterThan blockers. PRIYANKA RANI AND DHARMA KISHORE 1,5-Benzothiazepine, heterocycles, CNS-acting agents, anticancer, antimicrobial. 779-788