10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) Hyperlipidemia is the greatest risk factor contributing to atherosclerosis & occurrence of coronary heart disease & cerebrovascular accidents. Hence hypolipidemic drugs are extensively used as prophylactic agents to prevent such atherosclerosis induced disorders. But these hypolipidemic drugs are not free from adverse effects. Pancreatitis due to atorvastatin is a well known adverse effect and HMGCoA reductase inhibitors have also been reported to cause hyperglycemia and FDA has given a warning to this effect. Many plant derivatives and domestic remedies have been screened for their hypolipidemic action. More than 70 medicinal plants have been documented to have significant hypolipidemic action. This paper reviews these reports published in literatures in the last 5 years. This review indicates that the research has stopped with just reporting the effect of plant derivates and the findings are not translated into clinical research. Taking these finding forward is mandatory to develop new drugs in this area. Hence further research into identifying the active principle, conducting preclinical studies & if possible clinical studies is needed. VENU GOPALA RAO KONDA , MADHAVI.E, RUCKMANI.A AND VENKATARAMANA.Y Hyperlipidemia, Hypolipidemia, Medicinal plants. 729-740