International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 1 Issue 2
2010 (April - June)
Formulation and Evaluation of Floating-Mucoadhesive Tablet of Clarithromycin
The objective of the present study was to formulate and evaluate Floating–mucoadhesive tablets of clarithromycin for the treatment of Helicobacter pyloric (H.pylori) infection. Tablets were prepared by direct compression using directly compressible polymers such as HPMC K4M, HPMC K15M and carbopol 974P and were evaluated for drug - excipient compatibility, density, buoyancy test, mucoadhesion force, swelling study, drug content and in-vitro release profile. Sodium bicarbonate and citric acid were used for producing effervescent base for buoyancy of tablets. Analysis of drug release from tablet indicates drug release by zero order rate kinetics. No significant change was observed in physical appearance, drug content, floatability or in vitro dissolution pattern after storage at 45 °C / 75% RH for three months.
Zawar Laxmikant R.,Savaliya Pankaj J.,Bari Sanjay B.,Gattani Surendra G.
Floating mucoadhesive, clarithromycin, floating lag time, release kinetics.
-