10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) The objective of the present study was to evaluate the activity of the aqueous and ethanolic whole stem extracts of lessThan i greaterThan Oroxylum indicum lessThan /i greaterThan in hepatic injury produced with paracetamol.Wistar albino rats were used for the study.Multiple groups were taken for the study each consisting of six rats. Liver injury was induced using paracetamol 2 gm/kg, p.o.as a single dose. The two control groups received oral 1% CMC for 7 days, one of this group received paracetamol on 8 lessThan sup greaterThan th lessThan /sup greaterThan day. The four test groups received aqueous and ethanolic extracts of lessThan i greaterThan Oroxylum indicum lessThan /i greaterThan at two different dose levels of 250mg/kg and 500mg/kg (p.o.) respectively for 7 days, followed by the paracetamol administration on day 8, Standard control group received Silymarin as a comparable drug followed by Paracetamol. The serum parameters for liver such as ALT, AST, LDH, ALP, TB and TP were assessed along with the liver antioxidant enzymes LPO, Catalase and GSH. The histopathology analysis of liver was done on 8 lessThan sup greaterThan th lessThan /sup greaterThan day after due sacrificing the rats. Marker enzymes were analyzed in liver tissue. Both the extracts showed significant hepatoprotective activity comparable to that of Silymarin. AMOL NIMBA MORE, PRADEEP B. PARAB AND KISHORI G. APTE Paracetamol, Oroxylum indicum, Hepatoprotective, Silymarin, ALT, LDH. 255-265