10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) In the present study, the anti-inflammatory and analgesic effect of the hydroalcoholic extract of lessThan i greaterThan coccinia grandis lessThan /i greaterThan whole plant was investigated. The hydroalcoholic extracts of lessThan i greaterThan coccinia grandis lessThan /i greaterThan whole plant were ingested orally (p.o.) in two different doses, 200 and 400 (mg/kg body weight). The anti-inflammatory effect of lessThan i greaterThan coccinia grandis lessThan /i greaterThan was tested in: carrageenan-induced paw oedema in wistar albino rats and compared with the standard, diclofenac (10 mg/kg body weight). The analgesic effect of the hydroalcoholic effect of lessThan i greaterThan coccinia grandis lessThan /i greaterThan was evaluated in Swiss albino mice by usingEddys hot plate method and compared with the standard, aspirin (25 mg/kg body weight). The results showed that lessThan i greaterThan coccinia grandis lessThan /i greaterThan has significant reduction (p.0.01) in inflammation (200 mg/kg body weight) and (400 mg/kg body weight) as compared to the standard drug, diclofenac. In assessing analgesic effects, there is a significant (p lessThan 0.01) reduction in the paw licking for (400 mg/kg) and diclofenac (10 mg/kg) when compared to control. These results expressing that the extracts would possess analgesic and anti-inflammatory properties. All these effects and the changes in the behavioural activities could be suggested as contributory effects to the use of lessThan i greaterThan coccinia grandis lessThan /i greaterThan whole plant in the management of inflammation and painful conditions. CHANDAKA MADHU AND RAMANJANEYULU M Coccinia Grandis , Anti-inflammatory, Analgesic, Indomethacin 180-186