10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) The present study was carried out to evaluate the anti-inflammatory and hepatoprotective activities of different (Hydro-alcoholic, Methanolic, Ethylacetate, Hexane) extracts of lessThan i greaterThan Cleome chelidonii lessThan /i greaterThan root against carrageenan induced inflammation and Carbon Tetrachloride (CCl lessThan sub greaterThan 4 lessThan /sub greaterThan ) induced liver intoxication in rats. The extracts of lessThan i greaterThan C.chelidonii lessThan /i greaterThan root showed a dose dependent anti-inflammatory and hepatoprotection in rats. Among all the extracts, methanolic extracts produced maximum anti-inflammatorty activity (Percentage inhibition of maximal paw edema 53.39±1.2) and hepatoprotection (81.02%) at a dose of 400 mg/kg. The results were statistically significant (P lessThan 0.001) when compared to control group. The results of the present investigation clearly indicates that all the extracts of lessThan i greaterThan C.chelidonii lessThan /i greaterThan root possess dose dependent anti-inflammatory, hepatoprotective activities and this effect may be the result of presence various chemical constituents. SAMBASIVARAO ETHADI, RAJESWARARAO PRAGADAAND GANGARAO BATTU Cleome chelidonii, Root, Anti-inflammatory, Hepatoprotective, Carbon Tetrachloride, Carrageenan, Oedema. 111-119