10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 4 2013 (October - December) The present study deals with the effect of herbal powder of lessThan i greaterThan Vernonia cinerea lessThan /i greaterThan and lessThan i greaterThan Cuminum cyminum lessThan /i greaterThan on tissue defense system against CCl lessThan sub greaterThan 4 lessThan /sub greaterThan (carbon tetrachloride) induced hepatic injury in rats. CCl lessThan sub greaterThan 4 lessThan /sub greaterThan diluted with liquid paraffin oil (1:1 ratio) in a dose of 1ml / kg body wt was given intraperitoneally for 2 days. Herbal powder as a suspension of water (10mg / 100g body wt / day) was administered orally for 15 days to rats intoxicated with CCl lessThan sub greaterThan 4 lessThan /sub greaterThan . Induction with CCl lessThan sub greaterThan 4 lessThan /sub greaterThan resulted in an increase in the levels of aspartate transaminases, alkaline phosphatase, alanine transaminases and total bilirubin in serum. Post treatment with herbal powder reversed the deleterious effects of CCl lessThan sub greaterThan 4 lessThan /sub greaterThan and the enzymes were found to be near normal. These findings demonstrate the protective nature of herbal powder against CCl lessThan sub greaterThan 4 lessThan /sub greaterThan induced liver damage. A. NISHADH Hepatoprotective, carbon tetrachloride, Vernonia cinerea and Cuminum cyminu 65-68