10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 3 2013 (July - September) lessThan i greaterThan Acanthophora spicifera lessThan /i greaterThan , red algae are known to possess antioxidant activities. The objective of this study is to evaluate the ameliorative effect of the ethyl acetate extract of lessThan i greaterThan A. spicifera lessThan /i greaterThan against the puffer fish lessThan i greaterThan Arothron hispidus lessThan /i greaterThan induced biochemical alterations and oxidative stress. 24 Mice were divided into four groups were used in this study. Group 1 received normal saline as control, Group 2 – 4 were administered with skin extract of puffer fish lessThan i greaterThan A lessThan /i greaterThan . lessThan i greaterThan hispidus lessThan /i greaterThan . Group 3, 4 were pretreated with the ethyl acetate extract of lessThan i greaterThan A. spicifera lessThan /i greaterThan . Decreased level of AST, ALT, ALP, and Bilrubin were observed in the puffer fish extract administered group and it was significantly increased in drinking lessThan i greaterThan A. spicifera lessThan /i greaterThan extract groups. A raise of TBARS and the decrease of antioxidant enzymes were observed in the skin extract treated group. TBARS and antioxidant enzymes SOD, Catalase levels were significantly restored in the group drinking the lessThan i greaterThan A. spicifera lessThan /i greaterThan extract. Similarly it decreased the level of Cholestrol, Glucose, Protein, Creatinine, Urea The present study reveals the exposure of ethyl acetate extract of lessThan i greaterThan A. spicifera lessThan /i greaterThan considerably reduced the effect of puffer fish lessThan i greaterThan A lessThan /i greaterThan . lessThan i greaterThan hispidus lessThan /i greaterThan induced toxicity in mice. K. MOHANA PRIYA AND SAMANTA S. KHORA Acanthophora spicifera, Arothron hispidus, Oxidative stress, Biochemical alterations. 1043-1052