10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 3 2013 (July - September) To investigate the analgesic and anti-inflammatory properties of seed extracts of lessThan i greaterThan Diplocyclos palmatus lessThan /i greaterThan (L) C. Jeffrey. Three extracts of different polarity of lessThan i greaterThan Diplocyclos palmatus lessThan /i greaterThan (L) C. Jeffrey seeds were tested for their analgesic and anti-inflammatory activities. Analgesic activity was evaluated using the hot plate and acetic acid-induced writhing in mice. Anti-inflammatory activity was evaluated using carrageenan induced rat paw edema and cotton pellet granuloma in rats. Pretreatment with ethanolic extract of lessThan i greaterThan Diplocyclos palmatus lessThan /i greaterThan (L) C. Jeffrey at 100, 200 and 400 mg/kg showed significant dose dependent analgesic and anti-inflammatory effects in acetic acid induced pain model, carrageenan induced rat paw edema and cotton pellet granuloma models, while petroleum ether extract and aqueous extract of lessThan i greaterThan Diplocyclos palmatus lessThan /i greaterThan (L) C. Jeffrey at 100, 200 and 400 mg/kg showed weak analgesic and anti-inflammatory effects. The findings in this study suggest that the ethanolic seed extract of lessThan i greaterThan Diplocyclos palmatus lessThan /i greaterThan (L) C. Jeffrey possesses analgesic and anti-inflammatory activities. PARAG KADAM AND SUBHASH L. BODHANKAR. Analgesic, Anti-inflammatory, Diplocyclos palmatus (L) C. Jeffrey, Carrageenan, Cotton pellet. 970-978