10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 3 2013 (July - September) To emphasis the designing of drug molecule for increased the potency to recovery the infectious diseases by developing interaction of ligands with target proteins in insilico method , provided for selecting a new series of title compounds for synthesis. Title compounds 3-chloro-1-[1-(2-hydroxyethyl)-2-methyl-1 lessThan i greaterThan H lessThan /i greaterThan -imidazol-5-yl]-4-substituted phenylazetidin-2-one (3a lessThan sub greaterThan 1-5 lessThan /sub greaterThan ) were synthesized by reaction of 2-(2-methyl-5-{[(substituted)phenylmethylidene]amino}-1 lessThan i greaterThan H lessThan /i greaterThan -imidazol-1-yl)ethanol (2a lessThan sub greaterThan 1-5) lessThan /sub greaterThan and triethanolamine in the presence of chloro acetyl chloride with constant stirring for 7hrs. The compounds were established on the basis of their elemental analysis, FT-IR, lessThan sup greaterThan 1 lessThan /sup greaterThan HNMR and MS spectral data. The lipophilicity (logP) and ADME toxicity study was proven the drug likeness properties as in compounds 3a lessThan sub greaterThan 1-5 lessThan /sub greaterThan and activity efficacy of the 3a lessThan sub greaterThan 1-5 lessThan /sub greaterThan were typical which predicted by the best free energy poses interaction of target protein as compared to standard drugs. Thus it was observed that, both insilico and in vitro studies were parallely indicated the activities and identified the imidazole derivatives acted as an antimicrobial agent. RAJKUMAR MOHANTA AND SUSANTA KUMAR SAHU Docking energies, Imidazole derivatives, ADME and Antimicrobial activity. 758-766