DNA BINDING AND ANTI-MICROBIAL STUDIES OF Ag(II) AND Cu(II) METAL COMPLEXES CONTAINING MIXED LIGANDS OF 1,10- PHENANTHROLINE AND 8-HYDROXYQUINOLINE.

10.22376/ijpbs.2019.10.1.p1-12

Volume 4 Issue 3 2013 (July - September) DNA BINDING AND ANTI-MICROBIAL STUDIES OF Ag(II) AND Cu(II) METAL COMPLEXES CONTAINING MIXED LIGANDS OF 1,10- PHENANTHROLINE AND 8-HYDROXYQUINOLINE. The two new complexes Ag(L lessThan sub greaterThan 1 lessThan /sub greaterThan ) lessThan sup greaterThan 2 lessThan /sup greaterThan L lessThan sub greaterThan 2 lessThan /sub greaterThan (PF lessThan sub greaterThan 6 lessThan /sub greaterThan ) lessThan sub greaterThan 2 lessThan /sub greaterThan [Complex lessThan b greaterThan (1) lessThan /b greaterThan and Cu(L lessThan sub greaterThan 1 lessThan /sub greaterThan ) lessThan sup greaterThan 2 lessThan /sup greaterThan L lessThan sub greaterThan 2 lessThan /sub greaterThan (PF lessThan sub greaterThan 6 lessThan /sub greaterThan ) lessThan sub greaterThan 2 lessThan /sub greaterThan [Complex lessThan b greaterThan (2) lessThan /b greaterThan ] containing bioactive mixed ligand of typeL lessThan sub greaterThan 1 lessThan /sub greaterThan =8-Hydroxyquinoline and L lessThan sub greaterThan 2 lessThan /sub greaterThan =1,10-Phenanthroline have been synthesized and characterized by analytical and spectral methods. The binding constant of the complexes in 5 mM Tris-HCl/50 mM NaCl buffer at pH 7.2, are 25.79 x 10 lessThan sup greaterThan 6 lessThan /sup greaterThan M lessThan sup greaterThan -1 lessThan /sup greaterThan and 9.95 x 10 lessThan sup greaterThan 6 lessThan /sup greaterThan M lessThan sup greaterThan -1 lessThan /sup greaterThan for complex lessThan b greaterThan (1) lessThan /b greaterThan and lessThan b greaterThan (2) lessThan /b greaterThan respectively. . The synthesized compounds have been tested against microorganisms such as Gram positive bacteria ( lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan and lessThan i greaterThan Proteus vulgaris lessThan /i greaterThan ), Gram-negative bacteria ( lessThan i greaterThan Escherichia coli lessThan /i greaterThan and lessThan i greaterThan Pseudomonas aeruginosa lessThan /i greaterThan ) and fungus ( lessThan i greaterThan Aspergillus niger lessThan /i greaterThan ). A comparative study of the Minimum Inhibitory Concentration(MIC) values of the ligands and their complexes indicates that the complexes exhibit moderate antimicrobial activity than the free ligand and control. VEENA V PILLAI AND B.SREEKANTH Silver and Copper complexes, DNA Binding and Antimicrobial studies 739-747