10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 3 2013 (July - September) Triazole, oxadiazole and thiadiazole a five member heterocyclic nucleus has attracted a wide attention of the Chemist in search for the new therapeutic molecules. This heterocyclic nucleus play vital role in biological fields such as, Antimicrobial, Anticonvulsant, Anticancer, Anti-inflammatory activity.These Skeletons have its multiple potential against several activities. This review provides a brief summary of the medicinal chemistry of triazole ,Oxadiazole and thiadiazole system and highlights some examples of recent drug containing this moieties in the current literature. SHUBHANGI WAGHAMALE AND PRAVINA PISTE Triazole, Oxadiazole, Thiadiazole, Biological activities. 310-332