10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 3 2013 (July - September) The ethanolic extract of roots of lessThan i greaterThan Cocculus hirsutus lessThan /i greaterThan has been useful of various ailments (Tuberculosis, leprosy, skin diseases, dyspepsia, pruritis etc.). To determine the gastroprotective effect of lessThan i greaterThan Cocculus hirsutus lessThan /i greaterThan in model of ethanol induced ulcer rat, the ethanolic extract is given by oral gauges (100mg/kg) and (200mg/kg) half an hour prior to the administration of ethanol (1 ml of 96%).The antioxidant parameters were also determined in this model. lessThan i greaterThan C.hirsutus treatment lessThan /i greaterThan significantly reduced the ulcer index, lipid peroxidation (LPO) and significant increase in catalase, nitrite , thereby justifying it's use as an anti ulcerogenic agent. D.SWATHI1., K.V.S.R.G.PRASAD., P.RAMYA SREE. AND M.JALAIAH1. Cocculus hirsutus, Ulcer index, Lipid peroxidation, Catalase, Nitrite 74-78