10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 2 2013 (April - June) Dental biofilms play an important role in development of caries and periodontal disease, therefore their removal is integral to maintenance of oral hygiene. In the present study, different extracts prepared from lessThan i greaterThan Moringa oleifera, Murraya koenigii lessThan /i greaterThan , lessThan i greaterThan Psidium guajava lessThan /i greaterThan lessThan i greaterThan , Eclipta prostrata lessThan /i greaterThan and lessThan i greaterThan Phyllanthus fraternus lessThan /i greaterThan were screened for their effect on the growth, adherence and co-aggregation of a consortium of dental biofilm isolates. Results indicate, the test consortium was most susceptible to Ethanolic extract of lessThan i greaterThan M.koenigii lessThan /i greaterThan and Aqueous–Ethanolic extracts of lessThan i greaterThan P.guajava lessThan /i greaterThan and lessThan i greaterThan E.prostrata lessThan /i greaterThan at their minimum inhibitory concentrations of 0.5 mg/ml, 1 mg/ml and 5 mg/ml respectively and effectively suppressed adherence and co-aggregation of test consortium at sub-MIC concentrations. Subsequently, aqueous–ethanolic extracts of lessThan i greaterThan P.guajava lessThan /i greaterThan and lessThan i greaterThan E.prostrata lessThan /i greaterThan demonstrated a log reduction of 3.5 and 4.2 log lessThan sub greaterThan 10 lessThan /sub greaterThan cfu/ml respectively, in the viable count of dental biofilm load in-vitro. Hence, this study justifies the paradigm shift in oral care towards the use of nature-based products. NITHYA R.JOHN ,VIRAJ C.GALA AND CHHAYA S.SAWANT Dental biofilm; anti-bacterial activity; anti-adherence activity; anti-co-aggregation activity; Biofilm load 487-495