10.22376/ijpbs.2019.10.1.p1-12 Volume 4 Issue 2 2013 (April - June) Nonfermenting gram negative bacilli (NFGNB) cause serious infections in immuncompromised and hospitalized patients. They cause fatal lower respiratory tract infections in patients admitted to ICU's. The appearance of metallo ß-lactamases (MBL) genes and their spread among bacterial pathogens is a matter of concern. The present study was undertaken to know the prevalence of MBL producing NFGNB.NFGNB isolated from respiratory samples of patients admitted in various ICU's were identified. The antimicrobial susceptibility testing was done as per CLSI guidelines.. Imipenem resistant isolates were selected for the detection of MBL production by Imipenem-EDTA combined disc test. A total of 445 NFGNB were isolated, lessThan i greaterThan Acinetobacter baumannii lessThan /i greaterThan was the most common isolate followed by lessThan i greaterThan Pseudomonas aeruginosa lessThan /i greaterThan . Piperacillin/tazobactam and imipenem were the most effective antibiotics. 40 % of lessThan i greaterThan A. baumannni lessThan /i greaterThan and 20% of lessThan i greaterThan P.aeruginosa lessThan /i greaterThan isolates showed resistance to imipenem. MBL production was detected in 80.1% isolates. To conclude, carbapenem resistance and MBL production in NFGNB is not uncommon. VEENU GUPTA, DEEPINDER CHHINA AND AMARJEET KAUR. Carbapenem resistance, metallo ß-lactamases, NFGNB, ICUs 580-585